Io Rune
Io Rune is a low rune used in the runewords White, Black, Cure, Temper, Ground, Hearth, Bulwark, Delirium, Metamorphosis, Dream (Helm), Dream (Shield), Memory, Pride, Obsession, Unbending Will.
The Io Rune can also be used as ingredient for 2 different Horadric Cube recipes.
Io Rune like any other Diablo 2 Resurrected (D2R) Rune can be used to enhance a Socketed Item with new magical properties.
The rune adds +10 to Vitality property to any type of socketed item.
Io RuneHow to obtain Io Rune
The fastest way to get this rune on Battle.net is via trading, you can use the Item Price Checker to see how much Io Rune is worth.
Farming this rune by killing monsters is possible, check the drop rate table below for more information.
Another way to get it is via a horadric cube recipe that transmutes Hel runes into Io Rune.
Also, there's a chance this rune to drop from Hell's Forge Quest in Act 4 on Nigthmare and Hell difficulties.
Runewords with Io Rune
There are 15 runewords that can be made with Io Rune. You can also browse these Runewords in the Item Database.
 White Dol · Io Wands |
 Black Thul · Io · Nef Clubs, Hammers, Maces |
 Cure Shael · Io · Tal Barbarian Helms, Circlets, Druid Pelts, Helms |
Temper Shael · Io · Ral Barbarian Helms, Circlets, Druid Pelts, Helms |
Ground Shael · Io · Ort Barbarian Helms, Circlets, Druid Pelts, Helms |
Hearth Shael · Io · Thul Barbarian Helms, Circlets, Druid Pelts, Helms |
Bulwark Shael · Io · Sol Barbarian Helms, Circlets, Druid Pelts, Helms |
Delirium Lem · Ist · Io Barbarian Helms, Circlets, Druid Pelts, Helms |
Metamorphosis Io · Cham · Fal Barbarian Helms, Circlets, Druid Pelts, Helms |
 Dream (Helm) Io · Jah · Pul Barbarian Helms, Circlets, Druid Pelts, Helms |
 Dream (Shield) Io · Jah · Pul Paladin Shields, Shields |
 Memory Lum · Io · Sol · Eth Staves |
 Pride Cham · Sur · Io · Lo Amazon Spears, Polearms, Spears |
 Obsession Zod · Ist · Lem · Lum · Io · Nef Staves |
 Unbending Will Fal · Io · Ith · Eld · El · Hel Swords |
Horadric Cube Recipes with Io Rune
There are 2 recipes that are related to Io Rune. You can also see these Recipes in the Item Database.
Io Rune drop rate table
The monster with the highest drop chance of dropping Io Rune is The Countess on Nightmare difficulty in Tower Cellar Level 5 of Act 1. Farming the monsters listed below gives you the highest chance of getting that rune.