Lo Rune is a high rune used in the runewords Dragon, Brand, Hand of Justice, Fortitude (Weapon), Fortitude (Armor), Pride, Ice, Phoenix (Weapon), Phoenix (Shield), Grief, Destruction, Doom.
The Lo Rune can also be used as ingredient for 2 different Horadric Cube recipes.
Lo Rune like any other Diablo 2 Resurrected (D2R) Rune can be used to enhance a Socketed Item with new magical properties.
If socketed in Weapon the item will gain +20% Deadly Strike. When socketed in Armor, Helm, Shield it will get +5% to Maximum Lightning Resist.
The fastest way to get this rune on Battle.net is via trading, you can use the Item Price Checker to see how much Lo Rune is worth.
Farming this rune by killing monsters is possible, check the drop rate table below for more information.
Another way to get it is via a horadric cube recipe that transmutes Ohm runes into Lo Rune.
Unfortunately, this rune does not drop from Hell's Forge Quest.
There are 12 runewords that can be made with Lo Rune. You can also browse these Runewords in the Item Database.
There are 2 recipes that are related to Lo Rune. You can also see these Recipes in the Item Database.
The monster with the highest drop chance of dropping Lo Rune is Andariel on Hell difficulty in Catacombs Level 4 of Act 1. Farming the monsters listed below gives you the highest chance of getting that rune.