Plague is a Runeword "ChamShaelUm" in Diablo 2 Resurrected (D2R). It requires these 3 runes to be inserted into a socketed item in the exact order: Cham + Shael + Um . The eligible bases for Plague are the following: Swords, Assassin Claws, Daggers . There are 5 important benefits coming from Plague:
  • Opening wounds will cause the enemies to bleed over time. This is helpful against the Diablo clone.
  • There's a chance to do double damage on striking.
  • Gains extra skill points to all of the character's spells and abilities.
  • The enemies will take more damage from the poison spells.
  • Cleansing Aura
This is the only Runeword in the game that has X% Chance to cast Level X Lower Resist when struck attribute.
PlaguePlagueMythical Sword
Cham · Shael · Um
One-Hand Damage: 128 - 168 to 160 - 210
Durability: 44 of 44
Required Dexterity: 124
Required Strength: 147
Required Level: 67
Increased Melee Range: 1
Base Attack Speed: 0
20% Chance to cast Level 12 Lower Resist when struck
25% Chance to cast Level 15 Poison Nova on striking
Level (13 - 17) Cleansing Aura When Equipped
+(1 - 2) to All Skills
+20% Increased Attack Speed
+(220 - 320)% Enhanced Damage
-23% to Enemy Poison Resistance
+(0 - 29)% Deadly Strike (Based on Character Level)
+25% Chance of Open Wounds
Freezes target +3
Socketed (3)
Trade items on d2trader.net

How to obtain Plague

The fastest way to get this item on Battle.net is via trading, you can use the Item Price Checker to see how much Plague is worth.
Another way of getting this Runeword is by farming the runes and the base. Find the drop rates of these items in the Item Database.

Plague bases

The best base for Plague is Mythical Sword. Below is a list of all eligible 3 socket bases for Plague.