Natalya's Mark is a Set Scissors Suwayyah that is a part of the Natalya's Odium in Diablo 2 Resurrected (D2R). This elite Assassin Claw has a quality level of 22 and a treasure class of 87. It can be equipped only by an Assassin character. An important benefit coming from Natalya's Mark:
The enemy defense will be set to zero.
This is the only Set item in the game that has Ignore Target's Defense attribute.
The fastest way to get this item on Battle.net is via trading, you can use the Item Price Checker to see how much Natalya's Mark is worth.
Farming it by killing monsters is possible, check the drop rate table below for more information.
It can also be gambled but the chances are very slim.
Natalya's Mark drop rate table
The monster with the highest drop chance of dropping Natalya's Mark is Baal on Hell difficulty in The Worldstone Chamber of Act 5. Farming the monsters listed below gives you the highest chance of finding that item.
Natalya's Mark variants
Below is a list with different variants of Natalya's Mark. See the stats of its normal or upgraded variant.