Ist Rune is a mid< rune used in the runewords Delirium, Exile, Chains of Honor, Infinity, Call to Arms, Eternity, Obsession, Silence.
The Ist Rune can also be used as ingredient for 2 different Horadric Cube recipes.
Ist Rune like any other Diablo 2 Resurrected (D2R) Rune can be used to enhance a Socketed Item with new magical properties.
If socketed in Weapon the item will gain 30% Better Chance of Getting Magic Items. When socketed in Armor, Helm, Shield it will get 25% Better Chance of Getting Magic Items.
The fastest way to get this rune on Battle.net is via trading, you can use the Item Price Checker to see how much Ist Rune is worth.
Farming this rune by killing monsters is possible, check the drop rate table below for more information.
Another way to get it is via a horadric cube recipe that transmutes Mal runes into Ist Rune.
Also, there's a chance this rune to drop from Hell's Forge Quest in Act 4 on Hell difficulty.
There are 8 runewords that can be made with Ist Rune. You can also browse these Runewords in the Item Database.
There are 2 recipes that are related to Ist Rune. You can also see these Recipes in the Item Database.
The monster with the highest drop chance of dropping Ist Rune is The Countess on Hell difficulty in Tower Cellar Level 5 of Act 1. Farming the monsters listed below gives you the highest chance of getting that rune.